Publications

PUBLICATIONS:

  1. L. Lynch*, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. (2015) Regulatory iNKT cells lack PLZF and control Treg and macrophage homeostasis in adipose tissue. Nature Immunology, 16: 85-95. *corresponding author
  1. E. Kim, L. Lynch, Brennan, P, Cohen, N. and M.B. Brenner. The transcriptional program of iNKT cells. Invited Review. Seminars in Immunology, in press Jan 2015.
  1. M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. PMID: 25228503
  1. L. Lynch. Adipose iNKT cells. Invited Review. (2014) Immunology, doi: 10.1111/imm.122692014. 2014. PMID: 24673647
  1. 5. A. Tynan, C. Hearnden, E. Oleszycka, C. Lyons, G. Coutts, J. O’Connell, M. Corrigan, L. Lynch, M. Campbell, JJ. Callanan, K. Mok, J. Geoghegan, C. O’Farrelly, SM. Allan, H. Roche, D. O’Shea, and E. Lavelle. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. (2014) Diabetes. PMID: 24458363
  1. 6. Hogan, G. Gaoatswe, L. Lynch, M. Corrigan, C. Woods, J. O’Connell and D. O’Shea. Glucagon-like peptide-1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. (2014) Diabetalogica, 57(4):781-4. PMID: 24362727
  1. L. Lynch*, M. Nowak, B. Varghese, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O’Shea, C. O’Farrelly, and M.A. Exley. Adipose Tissue Invariant Natural Killer T Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulation Cytokine Prodution. (2012) Immunity, 21;37(3):574-87. PMID: 22981538 *corresponding author
  1. 8. L. Szereday, E. Miko, M. Meggyes, A. Barakonyi, B. Farkas, J. Bodis, Lynch, Cliona O’Farrelly and J. Szekeres-Bartho. Decidual haematopoietic stem cells in first trimester pregnancy. (2012). American J Reproductive Immunology 67(1):9-16. PMID: 21682790
  1. M.A. Exley, L. Lynch, B. Varghese, M. Nowak, N. Alatrakchi, and S. Balk. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects [review]. Invited Review: Clinical Applications of NKT cells. (2011) Clin Immunol. 140(2):184-95. PMCID: PMC3143311
  1. 10. J O’Connell, L Lynch, A Hogan, TJ Cawood, and D O’Shea. Preadipocyte factor-1 is associated with metabolic profile in severe obesity. (2011). Journal of Clinical Endocrinology and Metabolism, 96(4) 680-684. PMID: 21252254
  1. 11. E. Hogan, AM. Tobin, T. Ahern, M.A. Corrigan, G. Gaoatswe, R. Jackson, V. O’Reilly, L. Lynch, D.G Doherty, P.N. Moynagh, B. Kirby, J. O’Connell, and D. O’Shea. Glucagon like peptide -1 (GLP-1) and the regulation of human invariant natural killer T cells – lessons from obesity, diabetes and psoriasis. (2011). Diabetalogica, 54(11):2745-2754. PMID: 21744074
  1. A.E. Hogan, M.A. Corrigan, V . O’Reilly, G. Gaoatswe, J. O’Connell, D.G. Doherty, L. Lynch, and D. O’Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. (2011) Clin Immunol, 40(3):229-35. PMID: 21684213
  1. A.M. Tobin, L. Lynch, B. Kirby, and C. O’Farrelly. Natural killer cells in psoriasis. Review. (2011) J. Innate Immunity, 3(4):403-410. PMID: 21613780
  1. 14. O’Shea D, Cawood TJ, O’Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. (2010), Jan 25;5(1):e8660. PMID: 20107494
  1. M. Nowak, L. Lynch, S. Yue, A. Ohta, M. Sitkovsky, S.P. Balk, and M.A. Exley. The A2aR adenosine receptor controls cytokine production in iNKT cells. (2010). Eur J Immunol, 40(3):682-687. PMID: 20039304
  1. J.J. O’Connell, L. Lynch, T.J. Cawood and D. O’Shea. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. (2010). PLoS One, e9997. PMID: 20376319
  1. 17. A. O’Donovan, B.M. Hughes, G.M. Slavich, Lynch, M.T. Cronin, C. O’Farrelly, and K. Malone. Clinical anxiety and interleukin 6: Evidence for specificity in emotion biology relationships. (2010) Brain Behav Immun, 24(7):1074-7. PMID: 20227485
  1. L. Lynch, D O’ Shea, D.C. Winter, J. Geoghegan, D.G. Doherty and C.O’Farrelly. Invariant NKT Cells and CD1d-positive Cells Amass in Human Omentum and are Depleted in Patients with Cancer and Obesity. (2009) Eur. J. Immunology, 39(7):1893-1901. PMID: 19585513
  1. L. Lynch, J. O’Connell, A. Kwasnik, T. Cawood, C.O’ Farrelly and D. O’Shea. Are natural killer cells protecting the metabolically healthy obese? (2009) Obesity (Silver Spring),17:601-605. PMID: 19238145
  1. E. McGrath, E.J. Ryan, L. Lynch, L. Golden-Mason, C. O’Herlihy, M. Eogan, and C. O’Farrelly. Cycle-Related Changes in Endometrial Natural Killer Cell Expression of CD94, CD158a and CD158b are Associated with Infertility (2008). American Journal of Reproduction, 61:265-276. PMID: 19260857
  1. L. Lynch, M. Eogan, L. Golden-Mason, C. O’Herlihy and C. O’Farrelly. Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? (2006). Human Reproduction, 22:919-26. PMID: 17208945 This publication was been nominated for the 9th Royan International Research Award.
  1. L. Lynch, D. O’Donoghue, J. Dean, J. O’Sullivan, C. O’Farrelly and L.Golden-Mason. Detection and Characterization of Haematopoietic Stem Cells in the Human Small Intestine. (2006) Journal of Immunology, 176: 5199-5204. PMID: 16621984

BOOK CHAPTERS:

  1. M.A. Exley, L. Lynch, M. Nowak. NKT Cells of Cancer Patients and How Models Can Inform Therapeutic Plans (2012) [chapter]. In: Natural Killer T cells. Balancing the Regulation of Tumor Immunity. Terabe M, Berzofsky JA, editors. New York: Springer; 2012. pp. 129-52.