[metaslider id=37]PUBLICATIONS:
- L. Lynch*, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. (2015) Regulatory iNKT cells lack PLZF and control Treg and macrophage homeostasis in adipose tissue. Nature Immunology, 16: 85-95. *corresponding author
- E. Kim, L. Lynch, Brennan, P, Cohen, N. and M.B. Brenner. The transcriptional program of iNKT cells. Invited Review. Seminars in Immunology, in press Jan 2015.
- M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. PMID: 25228503
- L. Lynch. Adipose iNKT cells. Invited Review. (2014) Immunology, doi: 10.1111/imm.122692014. 2014. PMID: 24673647
- 5. A. Tynan, C. Hearnden, E. Oleszycka, C. Lyons, G. Coutts, J. O’Connell, M. Corrigan, L. Lynch, M. Campbell, JJ. Callanan, K. Mok, J. Geoghegan, C. O’Farrelly, SM. Allan, H. Roche, D. O’Shea, and E. Lavelle. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. (2014) Diabetes. PMID: 24458363
- 6. Hogan, G. Gaoatswe, L. Lynch, M. Corrigan, C. Woods, J. O’Connell and D. O’Shea. Glucagon-like peptide-1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. (2014) Diabetalogica, 57(4):781-4. PMID: 24362727
- L. Lynch*, M. Nowak, B. Varghese, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O’Shea, C. O’Farrelly, and M.A. Exley. Adipose Tissue Invariant Natural Killer T Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulation Cytokine Prodution. (2012) Immunity, 21;37(3):574-87. PMID: 22981538 *corresponding author
- 8. L. Szereday, E. Miko, M. Meggyes, A. Barakonyi, B. Farkas, J. Bodis, Lynch, Cliona O’Farrelly and J. Szekeres-Bartho. Decidual haematopoietic stem cells in first trimester pregnancy. (2012). American J Reproductive Immunology 67(1):9-16. PMID: 21682790
- M.A. Exley, L. Lynch, B. Varghese, M. Nowak, N. Alatrakchi, and S. Balk. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects [review]. Invited Review: Clinical Applications of NKT cells. (2011) Clin Immunol. 140(2):184-95. PMCID: PMC3143311
- 10. J O’Connell, L Lynch, A Hogan, TJ Cawood, and D O’Shea. Preadipocyte factor-1 is associated with metabolic profile in severe obesity. (2011). Journal of Clinical Endocrinology and Metabolism, 96(4) 680-684. PMID: 21252254
- 11. E. Hogan, AM. Tobin, T. Ahern, M.A. Corrigan, G. Gaoatswe, R. Jackson, V. O’Reilly, L. Lynch, D.G Doherty, P.N. Moynagh, B. Kirby, J. O’Connell, and D. O’Shea. Glucagon like peptide -1 (GLP-1) and the regulation of human invariant natural killer T cells – lessons from obesity, diabetes and psoriasis. (2011). Diabetalogica, 54(11):2745-2754. PMID: 21744074
- A.E. Hogan, M.A. Corrigan, V . O’Reilly, G. Gaoatswe, J. O’Connell, D.G. Doherty, L. Lynch, and D. O’Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. (2011) Clin Immunol, 40(3):229-35. PMID: 21684213
- A.M. Tobin, L. Lynch, B. Kirby, and C. O’Farrelly. Natural killer cells in psoriasis. Review. (2011) J. Innate Immunity, 3(4):403-410. PMID: 21613780
- 14. O’Shea D, Cawood TJ, O’Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. (2010), Jan 25;5(1):e8660. PMID: 20107494
- M. Nowak, L. Lynch, S. Yue, A. Ohta, M. Sitkovsky, S.P. Balk, and M.A. Exley. The A2aR adenosine receptor controls cytokine production in iNKT cells. (2010). Eur J Immunol, 40(3):682-687. PMID: 20039304
- J.J. O’Connell, L. Lynch, T.J. Cawood and D. O’Shea. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. (2010). PLoS One, e9997. PMID: 20376319
- 17. A. O’Donovan, B.M. Hughes, G.M. Slavich, Lynch, M.T. Cronin, C. O’Farrelly, and K. Malone. Clinical anxiety and interleukin 6: Evidence for specificity in emotion biology relationships. (2010) Brain Behav Immun, 24(7):1074-7. PMID: 20227485
- L. Lynch, D O’ Shea, D.C. Winter, J. Geoghegan, D.G. Doherty and C.O’Farrelly. Invariant NKT Cells and CD1d-positive Cells Amass in Human Omentum and are Depleted in Patients with Cancer and Obesity. (2009) Eur. J. Immunology, 39(7):1893-1901. PMID: 19585513
- L. Lynch, J. O’Connell, A. Kwasnik, T. Cawood, C.O’ Farrelly and D. O’Shea. Are natural killer cells protecting the metabolically healthy obese? (2009) Obesity (Silver Spring),17:601-605. PMID: 19238145
- E. McGrath, E.J. Ryan, L. Lynch, L. Golden-Mason, C. O’Herlihy, M. Eogan, and C. O’Farrelly. Cycle-Related Changes in Endometrial Natural Killer Cell Expression of CD94, CD158a and CD158b are Associated with Infertility (2008). American Journal of Reproduction, 61:265-276. PMID: 19260857
- L. Lynch, M. Eogan, L. Golden-Mason, C. O’Herlihy and C. O’Farrelly. Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? (2006). Human Reproduction, 22:919-26. PMID: 17208945 This publication was been nominated for the 9th Royan International Research Award.
- L. Lynch, D. O’Donoghue, J. Dean, J. O’Sullivan, C. O’Farrelly and L.Golden-Mason. Detection and Characterization of Haematopoietic Stem Cells in the Human Small Intestine. (2006) Journal of Immunology, 176: 5199-5204. PMID: 16621984
BOOK CHAPTERS:
- M.A. Exley, L. Lynch, M. Nowak. NKT Cells of Cancer Patients and How Models Can Inform Therapeutic Plans (2012) [chapter]. In: Natural Killer T cells. Balancing the Regulation of Tumor Immunity. Terabe M, Berzofsky JA, editors. New York: Springer; 2012. pp. 129-52.